Choices that have an impact on manufacturing are made all throughout the writing process. A prime example is the selection of margins. If you decide to use something too small – the software will do it – you could be encouraging everything from broken spines (no matter how good a quality the production was) to book information being cut off (either by being larger than the machines can print, or by the minimum page trim all bound books get).
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This section is drawn from http://www.gregathcompany.com/publish/design/margins.html

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